The present study was designed to investigate the interaction of Allium sativum Linn (Garlic) and Gymnema sylvestre R. Br. (Gymnema) for their antihyperlipidemic activity by using the laboratory animals. The hyperlipidemia was induced by atherogenic diet in Sprague Dawely female rats weighing 200-250 gms. Hydroalcoholic extract of the Allium sativum Linn bulb and Hydroalcoholic extract of Gymnema sylvestre R. Br. leaves were administered in dose of 200 mg/Kg body weigth, p.o. (orally) individually and in combination of 100 mg/Kg of both the extracts as well as 300 mg/Kg of both the extracts to atherogenic diet induced rats for seven days. After seven days, blood samples were collected from the animal and serum was separated from each sample and serum samples were analyzed spectrophotometrically for the estimation of serum lipid profile using diagnostic kits. Statistical analysis of the result was done using one-way analysis of variance (ANOVA) followed by Tukey’s test. Data were considered statistically significant at P value < 0.05. The result showed that treatment of rats with single and combined extracts gave rise to highly significant reductions in serum total cholesterol, serum triglyceride level, LDL, VLDL, atherogenic index and elevation in the serum HDL-C level and HDL- ratio. It was concluded from the study that antihyperlipidemic activity of combined extract of Garlic and Gymnema is higher in low dose combination and highest in high dose combination than individual extracts of garlic and Gymnema.
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